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Figure 2.
Figure 2. The Sequence Alignment of ICAM-1 with ICAM-3 and
ICAM-5As shown in the figure, ICAM-1, ICAM-3, and ICAM-5 align
very well. The conserved residues include all cysteines
(yellow), three integrin binding residues (cyan), those involved
in the D4–D4 dimerization interface (residues forming a salt
bridge are in green and hydrophobic contacts are in
yellow-green), and those involved in the D3–D4 bending
interface (magenta). In this figure, each domain's first residue
is manifest with its label, β strands are marked above the
ICAM-1 sequence, and every tenth residue is marked with a dot
above the ICAM-1 sequence. In addition, glycosylation sites are
colored in red, whereas the disordered 16 residues in D4 of the
D3–D5 crystal structure are shaded in gray.
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