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Figure 1.
FIG. 1. The schematic biosynthesis of anticoagulant heparan
sulfate. Five steps are involved in the biosynthesis of HS after
the polysaccharide backbone is made. The numbers indicate the
positions of each sugar unit. Both
N-deacetylase/N-sulfotransferase and C[5]-epimerase
modifications are indicated in red. The 2-O-sulfotransferase and
6-O-sulfotransferase modifications are indicated in black and
blue, respectively. The 3-O-sulfotransferase modification is
indicated in purple. For clarity, we have indicated the
3-O-sulfotransferase isoform 1 modifications only in this
figure. GlcUA, glucuronic; IdoUA, iduronic acid; Glc,
glucosamine.
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