Figure 1.
Figure 1 Location and structural context of histone Sin mutants.
(A) Overview of the NCP structure, viewed down the superhelical
axis. Only half of the DNA and associated proteins are shown.
SHLs are indicated by italic numbers from 0.5 (flanking the
nucleosomal dyad) to 6.5 (at the entry and exit point of the
DNA). The locations of the H4 L1 loop and the H3 L2 loop are
indicated in green and blue, respectively. Histone H3 is colored
in blue, H4 in green, H2A in yellow, and H2B in red. The box
indicates the location of Sin mutants. The nucleosomal dyad is
indicated ( ).
(B) Close-up of the Sin region showing the five residues
affected by Sin mutations. Dotted lines represent hydrogen
bonds. (C) Location of H4 Val-43 in the hydrophobic core at the
underside of the L1L2 loop arrangement. The view is similar as
in (B), with a slight rotation around the y-axis.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO J
(2004,
23,
260-271)
copyright 2004.
).
(B) Close-up of the Sin region showing the five residues
affected by Sin mutations. Dotted lines represent hydrogen
bonds. (C) Location of H4 Val-43 in the hydrophobic core at the
underside of the L1L2 loop arrangement. The view is similar as
in (B), with a slight rotation around the y-axis.