Figure 1.
Figure 1. Ribbon diagram of the nucleotide bound protein. The
ribbon diagram of monomer A of the Mg^2+GDP complex of the Ffh
NG domain is oriented to view into the active site. The -helical
N domain is in light blue, and the G domain is in light green.
The motif I P-loop at the center of the G domain interacts with
the phosphate groups of GDP (ball-and-stick). Motif II to the
left, and motif III to the center right (indicated), interact
with the bound magnesium ion through intervening water
molecules. The hydrated magnesium ion is shown as a CPK
representation. The carboxylate group of Asp248 hydrogen-bonds
the guanine base; the carboxylate of Asp135 contributes to the
second coordination sphere of the magnesium in monomer A, but is
usually found in a different conformation (see text).
The above figure is reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2004,
54,
222-230)
copyright 2004.
-helical
N domain is in light blue, and the G domain is in light green.
The motif I P-loop at the center of the G domain interacts with
the phosphate groups of GDP (ball-and-stick). Motif II to the
left, and motif III to the center right (indicated), interact
with the bound magnesium ion through intervening water
molecules. The hydrated magnesium ion is shown as a CPK
representation. The carboxylate group of Asp248 hydrogen-bonds
the guanine base; the carboxylate of Asp135 contributes to the
second coordination sphere of the magnesium in monomer A, but is
usually found in a different conformation (see text).