Figure 1 - full size

Figure 1. Figure 1 Domain organization of CFTR. The five domains of CFTR are shown. Also indicated is a putative nucleotide-binding domain association in which the ATP-binding site of one NBD is opposed by the signature sequence of the other NBD. Inactivity at the NBD1 ATP-binding site is indicated by Ser residues in place of the catalytic Glu and His in addition to His residues substituted for the Gln and central Gly in the NBD2 signature sequence.

The above figure is reprinted from an Open Access publication published by Macmillan Publishers Ltd: EMBO J (2004, 23, 282-293) copyright 2004.