Figure 1.
Figure 1: Structure of the Ago2 PAZ domain from D. melanogaster.
a, Stereoview of the ensemble of 15 lowest-energy NMR
structures. Helices are shown in green, -strands
in blue. Secondary structure elements are labelled by residue
numbers (compare with Supplementary Fig. S1). b, Ribbon
representation of the Ago2 PAZ domain. Secondary structure
elements are labelled. The side chains of residues that were
mutated are annotated and coloured in gold. c, Comparison of the
central five-stranded -barrel
of the PAZ domain to a canonical OB-fold in the E. coli Rho
protein30. Related secondary structure elements are coloured in
blue. The inserted 3,
4,
3
module of the PAZ domain is shown in orange. The respective
topology of the two -barrels
is indicated schematically at the bottom.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2003,
426,
465-469)
copyright 2003.
-strands
in blue. Secondary structure elements are labelled by residue
numbers (compare with Supplementary Fig. S1). b, Ribbon
representation of the Ago2 PAZ domain. Secondary structure
elements are labelled. The side chains of residues that were
mutated are annotated and coloured in gold. c, Comparison of the
central five-stranded 
3
module of the PAZ domain is shown in orange. The respective
topology of the two