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Figure 2.
Figure 2. Stereo Views of Scyptolin A Binding to Porcine
Pancreatic Elastase(A) Ribbon plot of elastase with the initial
(F[o]-F[c]) electron density map of scyptolin A at a contour
level of 3 σ. The final model of scyptolin A is drawn into the
density. The side chains of the catalytic triad of elastase
are given for reference (pink).(B) Stereo view of scyptolin A
bound to elastase represented by its molecular surface. The
catalytic triad beneath the surface is shown; the putative
nucleophilic attack of the serine is indicated by a dashed red
line. The inhibitor with its rigid cyclic peptide structure sits
snugly in the active center pocket.
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