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Figure 1.
Figure 1: a, Human prothrombin and its cofactor SC.
Cleavage sites in the latter are indicated by arrowheads.
b, SC homologues: CAD46494 (refs 8, 9); FbpA,
fibrinogen-binding protein A (ref 22); NP_687847; SfbX,
Streptococcus pyogenes fibronectin (FN)-binding protein (ref 23);
and vWbp (ref 7). The sequence that directs cell-wall sorting of SfbX
is indicated by a diamond; the RGD triplet is also indicated. Gla,
gamma-carboxyglutamic acid domain; K, kringle domain;
L, light chain; C, cytoplasmic tail; D1/D2,
alpha-helical domains; Fn, FN-binding repeats (refs 24,25);
M, membrane-spanning peptide; P/S,
proline/serine-rich region; R, SC C-terminal repeats; RL4,
domain homologous to the large ribosomal
subunit L4; S, signal sequence.
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