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Figure 1.
Figure 1. Schematic representation of the rrangement of regulatory and functional domains in smooth muscle yosin
light chain kinase based on genetic and biochemical studies (Olsen et al., 1990) ad their relationship to telokin. The
Figure shows the positins of the immunoglobuin-like sequence motifs types I and II) that are omologous to those
observed in twitchin (Benian et al., 1989). t also ives the location in the sequnce of the catalytic and calmodulin
binding domains (CAM). The segmen responsible for auto-inhibition o MLCK is ocated between residues 786 and 805
and overaps the calmodulin binding region (Ito et al., 1991).
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