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Figure 1.
FIG. 1. COX substrate binding modes. Stereo diagram of the
inhibitory binding mode of arachidonic acid to COX-2 (blue)
aligned with the productive binding mode, observed in COX-1
(beige). The substrate is nominally rotated 180° between the
two orientations, resulting in different coordination of the
carboxylic acid group. Amino acids shown are within van der
Waals contact of diclofenac except for Arg-120, Val-434, and
Arg-513, added for reference. Red text indicates the position of
the three amino acid differences between COX-1 and COX-2 within
the active site. The superposition was performed using amino
acids 113-122, 344-355, 385-391, and 522-532 and coordinate
Protein Data Bank files 1CVU [PDB]
and 1DIY [PDB]
. All molecular graphics were generated with Ribbons and
rendered with POV-Ray (36).
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