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Figure 1.
Figure 1. Overall structure of LecB. (a) Ribbon
representation of the LecB monomer showing one sheet in blue and
one in green. The two calcium ions are shown as red spheres. (b)
The LecB tetramer with each monomer shown in a different colour.
Each monomer is labeled A, B, C or D according to the
nomenclature used in the text. (c) Conserved water molecules in
the native, calcium-bound LecB structures are shown superimposed
on a C^a trace of the LecB tetramer. The view is identical with
that in (b). The water molecules that occupy the waste of the
tetramer are shown in dark blue. Two completely buried water
molecules are shown in red. Orange water molecules are located
at the otherwise largely hydrophobic AB interface. Conserved
water molecules located close to the monosaccharide binding site
are coloured green. The remaining conserved water molecules that
are scattered over the surface of the tetramer are coloured in
light blue.
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