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Figure 1.
Figure 1. Ionotropic glutamate receptor domain organization and
agonist structure. (a) iGluR domain organization. Polypeptide
segments S1 and S2 comprise the water-soluble, ligand-binding
core and the S1S2J construct studied here includes residues 392
-506 (S1) and 632 -775 (S2) linked together by a Gly -Thr
dipeptide. The amino terminal domain (ATD) and the transmembrane
segments are not contained within the S1S2J construct. (b)
Chemical structures of glutamate and 5-substituted willardiines.
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