Figure 1.
Fig. 1. Structure of the human Il-6/IL-6R /gp130 hexameric
complex. (A) Schematized view of the domain structure of IL-6,
IL-6R , and gp130. (B)
Top view of a SigmaA-weighted 2F[obs] - F[calc] electron density
map contoured at 2 of the hexamer.
The gp130 molecules are colored in cyan and blue, IL-6R molecules are
colored green and purple, and IL-6 molecules are colored pink
and red. The coloring scheme is maintained in all figures. (C)
Tilted side view of the hexamer rotated 90° toward the
viewer and tilted on the diagonal from (B). The five unique
interfaces are labeled as sites I, IIa, IIb, IIIa, and IIIb.
Figures were prepared with MOLSCRIPT (21) and Raster3D (22).
The above figure is reprinted
by permission from the AAAs:
Science
(2003,
300,
2101-2104)
copyright 2003.
/gp130 hexameric
complex. (A) Schematized view of the domain structure of IL-6,
IL-6R 
of the hexamer.
The gp130 molecules are colored in cyan and blue, IL-6R 
90° toward the
viewer and tilted on the diagonal from (B). The five unique
interfaces are labeled as sites I, IIa, IIb, IIIa, and IIIb.
Figures were prepared with MOLSCRIPT (21) and Raster3D (22).