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Figure 1.
Figure 1: Comparison of native and sulphenyl-amide PTP1B. a,
Ribbon diagram of PTP1B. The phosphate-binding cradle is shown
in red, the WPD loop in green and the pTyr recognition loop in
gold. b, Superposition of native PTP1B (blue) and the
sulphenyl-amide-containing structure (orange), showing different
conformations of the pTyr recognition loop and the
phosphate-binding cradle. c, Electron density of the catalytic
cysteine and its neighbouring residues in reduced PTP1B (see
Supplementary Information). d, Electron density of the newly
identified sulphenyl-amide derivative of Cys 215. The electron
density maps in c and d are contoured at 1  .
All figures are generated using Aesop (M. Noble, Laboratory of
Molecular Biophysics, University of Oxford, unpublished).
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