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Figure 1.
Fig. 1. Overall structure of the yeast actin/gelsolin
segment-1 complex. Gelsolin (purple) binds to subdomains 1 and 3
of actin (yellow). Sixteen water molecules (aqua) contribute to
the actin-gelsolin binding interface. Eight water molecules
(red) form a network across the actin nucleotide binding cleft,
contacting residues in subdomains 1, 3, and 4 (red backbone).
The gelsolin-associated Ca^2+ ion is represented as pink. The
adenine nucleotide is also shown, with the Mg2+ ion in black.
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