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Figure 2.
Figure 2. Overall Structure of the Auto-Inhibitory
Conformation of p47^phox(A) Structure of the auto-inhibited
domain swapped dimer of p47^phox (156–340). The two monomers
are shown in red and green. The crystal structure of the SH3
domain of Abl (1AB0) has been overlapped onto SH3[A] and is
shown in yellow. The lower part of Figure 2A shows an expanded
view of this overlap.(B) Overall structure of the biological
monomer of auto-inhibited p47^phox. The SH3[A] and SH3[B]
domains are colored in blue and red, respectively and the
polybasic region in yellow. The secondary structural elements
are labeled according to the standard SH3 domain nomenclature.
SH3[A] and SH3[B] are related by an approximate 2-fold axis that
is perpendicular to the plane of the page.
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