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Figure 1.
Figure 1 Structure of the ActRIIB:activin A complex. (A) Ribbon
diagram of the complex. The activin A dimer is shown in light
and dark blue for each monomer and the fingers are labeled F1
-F4; ActRIIB models are represented in yellow and red CPK atoms
with the hydrophobic cluster (Y60, W78, F101) are shown in grey.
(B) Superposition of the P4[1] (black) and P4[1]2[1]2 (red and
blue) crystal forms. (C) Electron density showing the edge of
the hydrophobic interface and the intramolecular salt bridge
between K102 and D104 (activin A shown in red; ActRIIB, yellow).
(D) Expanded stereo view of the electron density of the complex
interface. Electron density is from a simulated annealing
composite omit map contoured at 1.5 and 0.9  ,
respectively.
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