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Figure 1.
Figure 1. Solution Structure of a Gads SH3-C Domain –
SLP-76 Peptide Complex(A) Stereo view of a superposition of 20
lowest-energy structures of the Gads SH3-C domain – SLP-76
peptide complex in backbone traces. The Gads SH3-C domain
(residues 265–321) is shown in green and the SLP-76 peptide in
violet. The peptide has the sequence A^1PSIDRSTKPA^11, of which
the first ten residues were taken from the Gads SH3-C –
binding site in SLP-76, and the last Ala was added to reduce end
effects. Ala11 does not interact with the SH3 domain (see Figure
3B) and is hence omitted from all figures for clarity.(B) Ribbon
representation of the same complex generated using coordinates
of the lowest-energy structure. The β strands and the RT- and
n-Src loops of the SH3 domain are labeled in black. The peptide
backbone is depicted in violet with side chains shown in pale
green or dark green (for residues located at the peptide-protein
interface).
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