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Figure 1.
Fig. 1. (a) Compound 1/IL-2 complex determined by x-ray
crystallography (Table 1). Compound 1 is shown in green sticks,
IL-2 in white ribbon. The B-C loop is not defined by the
electron density and is shown schematically in white spheres.
(b) Interaction of Compound 1 (green sticks) with IL-2 (white
sticks) taken from x-ray coordinates. Key contact side chains
are labeled; H-bonds and distances are shown by yellow dotted
lines. All molecular graphic images were produced with PYMOL (W.
L. DeLano, San Carlos, CA).
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