|
Figure 1.
Figure 1. Overview of the LC13 T Cell Receptor Complexed to
HLA-B8/FLRGRAYGL(A) Ribbon representation of the
LC13/HLA-B8/FLRGRAYGL complex. The α chain and β chain of LC13
TCR are shown in light red and blue, respectively. The HLA-B8
heavy chain and the β2-microglobulin domain are shown in light
and darker green, respectively. The bound EBV peptide is in
yellow, with the P7 Tyr residue shown in stick format.(B) A
close-up of the interface, in an orthogonal view to (A), with
the CDR regions color coded CDR1α, red; CDR2α, magenta;
CDR3α, blue; CDR1β, orange; CDR2β, green; and CDR3β, cyan.
Residues from CDR1 and CDR2 participating in polar contacts are
highlighted.(C) Involvement of the publicly encoded regions that
encompass CDR3 at the interface. The CDR3α loop residues and
their corresponding amino acid sequence are color coded with the
Vα backbone in red, N-region in dark blue, and Jα in dark
green; CDR3β loop residues are coded with the Vβ backbone in
orange; DβN-region light blue and Jβ light green. Residues P6
Ala, P7 Tyr, and P8 Gly of the FLRGRAYGL peptide are shown in
yellow. Part of the HLA-B8 α2 helix has been removed to
simplify the illustration. Selected residues from the HLA-B8 α1
and α2 helices are shown in gray.
|
