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Figure 1.
Figure 1. Overall Structures of the C1r CCP2-SP
AssembliesThe WT, S637A, and R446Q molecules are shown in green,
red, and cyan, respectively. The structure shown for R446Q is
that of molecule B of the R446Q dimer [17].(A) Superimposition
of the S637A and WT structures (stereo view). Loops are labeled
according to Perona and Craik [19]. a.s., active site.(B)
Superposition of the assemblies on the CCP2 module structures
(partial view), illustrating the divergent orientations of the
polypeptide chain in the SP domains.(C) Detailed view of the
hinge region in the three structures. Residues Pro432, Val433,
Cys434, and Cys560 are shown as balls and sticks.
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