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Figure 1.
Figure 1. Inhibitor structures and binding of NU2058 to
T160pCDK2 -cyclinA. a, Chemical structures of NU2058, NU6094,
NU6086 and NU6102. b, T160pCDK2 -cyclinA -NU2058 structure.
T160pCDK2 -cyclinA is drawn in ribbon representation. CDK2 is
purple and cyclin A is gold. NU2058 bound in the CDK2 active
site cleft is shown as a surface representation in green. c,
CDK2 -NU2058 hydrogen bond interactions. Schematic
representation of the conserved hydrogen bonds between backbone
atoms of CDK2 residues Leu 83 and Glu 81, located in the hinge
region, and NU2058. Hydrogen bonds are drawn as dotted lines.
Arrows pointing towards Phe 80 and Lys 89 indicate the
orientation of the inhibitor within the active site.
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