Figure 1 - full size

 

Figure 1.
Figure 1. Reaction of MtdAMethylene-H[4]MPT (-H[4]F) is oxidized to methenyl-H[4]MPT (-H[4]F) with NADP+ as cosubstrate. H[4]MPT is composed of a 7-methyl-6-ethyl-pterin, an aminobenzyl, a 1-desoxyribose, a ribose, a phosphate, and a 2-hydroxyglutarate moiety. H[4]F consists of a 6-methyl-pterin, a p-aminobenzoate, and a glutamate moiety. The two methyl groups painted in blue are only present in H[4]MPT. Methylene and methenyl groups are indicated in red.

The above figure is reprinted by permission from Cell Press: Structure (2002, 10, 1127-1137) copyright 2002.