|
Figure 1.
Figure 1. Comparison of the Chemical Structures of Several
b-Lactamase Ligands(A) Ampicillin, a b-lactamase substrate.(B)
Ceftazidime, a b-lactamase-resistant molecule. The R1 side chain
ubiquitous among b-lactams is labeled.(C) A boronic acid
transition-state analog inhibitor that contains the R1 side
chain from ceftazidime [9].(D) Compound 1, 3-[(4-chloroanilino)
sulfonyl]thiophene-2-carboxylic acid, a novel, competitive
inhibitor of b-lactamase.
|
