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Figure 2.
Figure 2. Sequence and Structural Alignment of Selected AHL
Synthases and GNATsThe sequence and topology of the AHL synthase
family is compared to the GCN5-related N-acetyltransferases. The
gray shaded regions are conserved sequence blocks within each
family that constitute the enzyme's “sequence signature.”
Residues are colored red to indicate acidic or hydrophilic, blue
for basic, and orange for other. Shaded residues are absolutely
conserved, and the boxed residues are homologous within each
family. Residues that comprise the core “phosphopantetheine
binding fold” were identified by LSQMAN using a 2.0 Å
cutoff and are indicated by black bars above the segments. The
Tetrahymena GCN5 residues that contact the pantetheine or acetyl
portion of the acetyl-CoA are indicated by “p” or “a,”
respectively.
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