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Figure 1.
Figure 1. Structure of the TonEBP -DNA complex. a, Overall
structure. The following scheme is used for all illustrations
except Fig. 3c: the N-terminal (RHR-N) and C-terminal (RHR-C)
domains of TonEBP are colored yellow and green, respectively.
Strands and helices are labeled; the lettering corresponds to
that used for NFAT1 (ref. 4). DNA is shown in the stick model.
The sequence of the DNA used in the crystals is shown below the
figure. b, Structure-based sequence alignment of human TonEBP
(T), NFAT1(N), and NF-  B
p52 (P) in the DNA-binding region. The numbering for TonEBP is
used. The secondary structure assignments for TonEBP are shown
as colored bars (  -helices)
and arrows (  -strands)
above the aligned sequences; those for NF- B
p52 are shown below the sequence. The colored blocks show
residues that participate in contacts to DNA (magenta), RHR-C
dimerization (green) and E'F loop dimerization (yellow).
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