|
Figure 1.
Figure 1. PSD-95 Domain Organization and Overall
Architecture of PSD-95 SH3-HOOK-GK Domains(A) PSD-95 domain
organization showing the conserved core of MAGUK proteins and
the fragment studied in this work (SH3-HOOK-GK).(B) SH3-HOOK-GK
model built using the GMP-bound structure and residues 439–445
and 502–508 from the apo form. In gold is shown the SH3
domain, in blue the HOOK domain, in green the GK domain, and in
magenta the last 12 residues C-terminal to the GK domain. The
dashed lines represent the disordered parts of the
molecule in both crystal forms. The residues represented in the
SH3 domain constitute the proline-rich peptide binding site. In
red are shown the regions in the SH3 and GK domains that
participate in crystallographic contacts in both crystal forms.
|
