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Figure 1.
Figure 1. The Ras-Byr2RBD Complex(a) Ribbon representation
showing Byr2RBD on the left and Ras on the right. Switch I is
shown in light blue, switch II is in dark blue, and the
nucleotide is in pink. The presumed helical segment in the
middle of the RBD is indicated as a dashed wavy line.(b)
Structure-based sequence alignment of the RBDs from Raf [13],
PI3-kinase [17], RalGDS [7], and Byr2 (this work), done with the
program STAMP [72]. Assignment of secondary structure elements
according to the program DSSP [73] is included for Byr2RBD;
dashed lines indicate disordered regions. Structurally related
regions are boxed and residues conserved as hydrophobic or polar
amino acids are in yellow and red, respectively. Residues
involved in the interaction with Ras are marked with green dots
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