Figure 1.
Figure 1. Overall structure of serpin-protease complex and
comparison with other serpins. a, Ribbon diagram of serpin 1B
A353K -trypsin S195A complex. RCL is gold; helices of both
serpin and trypsin are blue; -sheets
A, B and C of the serpin are light, medium and dark magenta,
respectively; and -sheets
of trypsin S195A are red. b, Superposition of active serpin 1K
(PDB code 1SEK) (cyan throughout; red reactive center) with
serpin 1B A353K (magenta throughout; gold reactive center). c,
Cleaved form of the serpin -1
antitrypsin (PDB code 9API) drawn by BOBSCRIPT31 and rendered by
POV-RAY32. The topological switch point at P16 for insertion of
the RCL as strand 4A is marked in (b,c).
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2001,
8,
979-983)
copyright 2001.
-sheets
A, B and C of the serpin are light, medium and dark magenta,
respectively; and 
-1
antitrypsin (PDB code 9API) drawn by BOBSCRIPT31 and rendered by
POV-RAY32. The topological switch point at P16 for insertion of
the RCL as strand 4A is marked in (b,c).