Figure 1.
Figure 1. (a) Chemical structure of TMC-95s including
diastereomers A to D. (b) The lead structure segment of TMC-95s
which contributes the most to proteasome inhibition. The S1 and
S3 residues, shown in blue, mark specific amino acid residues
that are major determinants for differential binding to
proteasomal subunits.
The above figure is reprinted
by permission from Elsevier:
J Mol Biol
(2001,
311,
543-548)
copyright 2001.
