Figure 1.
Figure 1. Decarboxylation of 5-nitro-3-carboxybenzisoxazole
2 proceeds through a charge-delocalized transition state 3 to
give salicylonitrile 4. Naphthalene disulfonate 1 was used to
elicit the decarboxylase antibody 21D8 through a covalent
linkage to keyhole limpet hemocyanin (KLH).
The above figure is reprinted
by permission from Elsevier:
J Mol Biol
(2000,
302,
1213-1225)
copyright 2000.
