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Figure 1.
Figure 1. Ligand Binding Constants for S1S2J(A) Domain
structure of iGluRs showing the S1 and S2 segments in turquoise
and pink, respectively. “Cut” and “link” denote the
edges of the S1S2 construct.(B) K[D] for ^3H-AMPA binding was
24.8 ± 1.8 nM.(C) IC[50] for displacement of ^3H-AMPA by
glutamate, kainate, and DNQX were 821 nM, 14.5 μM, and 998 nM,
respectively.
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