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Figure 1.
Figure 1. Comparison of P-LE to the Structure of E-LE
([17])(A) Ribbon representation of the optimal superposition of
P-LE and the previously described E-LE structure showing overall
similarity. P-LE is in blue and E-LE is in green. The bound
calcium ions in the two structures are precisely superimposed
and are represented as a single yellow sphere.(B) A ball and
stick representation of the superposition of P-LE and E-LE
residues in the vicinity of the SLe^X binding site. The coloring
scheme and superposition of calcium ions is identical to that in
Figure 1A. For clarity, only interactions with the bound calcium
in E-LE are shown as dashed lines. The stabilizing hydrogen bond
between Arg97 and Asp100 in E-selectin is also shown as a dashed
line. For residues that differ between E- and P-selectin,
E-selectin residues are listed first. All structure figures were
produced with MOLSCRIPT ( [20]) and RASTER3D ( [27]) except
where noted.
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