Figure 1.
Figure 1: The FGF1-FGFR2-heparin complex. a, View
perpendicular to the approximate dyad of the complex. FGFR2
domains 2 (D2) and 3 (D3) are cyan and magenta, respectively,
and FGF1 is green. The heparin molecule is in CPK
representation. b, View along the dyad. c, Amino-acid sequence
of the ligand-binding region of human FGFR2. Domains D2 and D3
are coloured as in a. Residues that interact with heparin and
FGF1 are highlighted in red and green, respectively. Regions of
secondary structure are boxed. -strands,
-helices
and 3[ 10] helices are indicated below the relative sequence. D3
residues 294-309, which were disordered in the crystals, are in
lower case.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2000,
407,
1029-1034)
copyright 2000.
-strands,
-helices
and 3[ 10] helices are indicated below the relative sequence. D3
residues 294-309, which were disordered in the crystals, are in
lower case.