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Figure 1.
Fig. 1. Structures of IL-1R1·IL-1  and
IL-1R1·IL-1ra. Shown is a comparison of the structures of
the IL-1R1·IL-1 complex
(left) and the IL-1R1·IL-1ra complex (right). The two
structures look very similar, but in the IL-1ra complex, the
third domain swings 20° away from the ligand. The receptor
is orientated such that the cell membrane, if present, would be
at the bottom of the figure. The amino terminus of the receptor
is at the top right, and the carboxyl terminus at the bottom.
The conserved binding site (Site A) lies between the first and
second immunoglobulin domains, whereas the second binding site
(Site B), which is utilized by IL-1 , but not by
IL-1ra, lies on the face of the third domain. The structures are
colored by change in solvent-accessible surface upon ligand
binding. The color scheme ranges from dark blue (<20 Å2) to red
(>90 Å2).
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