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Title
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The 2.0 A crystal structure of a heterotrimeric G protein.
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Authors
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D.G.Lambright,
J.Sondek,
A.Bohm,
N.P.Skiba,
H.E.Hamm,
P.B.Sigler.
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Ref.
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Nature, 1996,
379,
311-319.
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PubMed id
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Abstract
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The structure of a heterotrimeric G protein reveals the mechanism of the
nucleotide-dependent engagement of the alpha and beta gamma subunits that
regulates their interaction with receptor and effector molecules. The
interaction involves two distinct interfaces and dramatically alters the
conformation of the alpha but not of the beta gamma subunits. The location of
the known sites for post-translational modification and receptor coupling
suggest a plausible orientation with respect to the membrane surface and an
activated heptahelical receptor.
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