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Title
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Crystal structure of the tyrosine kinase domain of the human insulin receptor.
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Authors
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S.R.Hubbard,
L.Wei,
L.Ellis,
W.A.Hendrickson.
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Ref.
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Nature, 1994,
372,
746-754.
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PubMed id
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Abstract
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The X-ray crystal structure of the tyrosine kinase domain of the human insulin
receptor has been determined by multiwavelength anomalous diffraction phasing
and refined to 2.1 A resolution. The structure reveals the determinants of
substrate preference for tyrosine rather than serine or threonine and a novel
autoinhibition mechanism whereby one of the tyrosines that is autophosphorylated
in response to insulin, Tyr 1,162, is bound in the active site.
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