 |
|
Title
|
|
Four-fold structural repeat in the acid proteases.
|
|
|
Authors
|
|
T.L.Blundell,
B.T.Sewell,
A.D.McLachlan.
|
|
|
Ref.
|
|
Biochim Biophys Acta, 1979,
580,
24-31.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
The observation that the acid proteases contain two structurally equivalent
lobes related by a dyad through the active centre has been extended to show that
in endothiapepsin each lobe contains two similar halves related by a further
local dyad. In lobe 1 22 pairs of alpha-carbons are equivalent with a root mean
square deviation of 1.92 A. In lobe 2 17 pairs match within 2.31 A. Convergent
evolution or gene quadruplication may have occurred.
|
|
|
|