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Title
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Three-dimensional structure of calmodulin.
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Authors
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Y.S.Babu,
J.S.Sack,
T.J.Greenhough,
C.E.Bugg,
A.R.Means,
W.J.Cook.
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Ref.
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Nature, 1985,
315,
37-40.
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PubMed id
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Abstract
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The three-dimensional structure of calmodulin has been determined
crystallographically at 3.0 A resolution. The molecule consists of two globular
lobes connected by a long exposed alpha-helix. Each lobe binds two calcium ions
through helix-loop-helix domains similar to those of other calcium-binding
proteins. The long helix between the lobes may be involved in interactions of
calmodulin with drugs and various proteins.
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