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Title
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Nuclear magnetic resonance identification of "half-turn" and 3(10)-helix secondary structure in rabbit liver metallothionein-2.
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Authors
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G.Wagner,
D.Neuhaus,
E.Wörgötter,
M.Vasák,
J.H.Kägi,
K.Wüthrich.
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Ref.
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J Mol Biol, 1986,
187,
131-135.
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PubMed id
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Abstract
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Analysis of 1H-1H nuclear Overhauser effects and amide proton-C alpha proton
coupling constants in rabbit liver metallothionein-2 resulted in the
identification of two segments of 3(10)-helix and numerous secondary structure
elements of a novel type, which we call "half-turn". A half-turn can be
generated starting from a type II tight turn by rotation of phi 3 from +90
degrees to -90 degrees. Its appearance in metallothionein appears to be a
consequence of the constraints on the polypeptide conformation by the large
number of metal binding sites.
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