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Title
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Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans.
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Authors
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G.M.Benian,
J.E.Kiff,
N.Neckelmann,
D.G.Moerman,
R.H.Waterston.
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Ref.
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Nature, 1989,
342,
45-50.
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PubMed id
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Abstract
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The Caenorhabditis elegans gene unc-22 encodes a very large muscle protein,
called twitchin, which consists of a protein kinase domain and several copies of
two short motifs. The sequence of twitchin has unexpected similarities to the
sequences of proteins of the immunoglobulin superfamily, cell adhesion molecules
and vertebrate muscle proteins, including myosin light-chain kinase. These
homologies, together with results from earlier genetic and molecular analyses,
indicate that twitchin is involved in a novel mechanism of myosin regulation.
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