Abstract for PubMed entry 25592713

Title		Pyridine and pyridinone-based factor XIa inhibitors.
Authors		J.R.Corte, T.Fang, J.J.Hangeland, T.J.Friends, A.R.Rendina, J.M.Luettgen, J.M.Bozarth, F.A.Barbera, K.A.Rossi, A.Wei, V.Ramamurthy, P.E.Morin, D.A.Seiffert, R.R.Wexler, M.L.Quan.
Ref.		Bioorg Med Chem Lett, 2015, 25, 925-930.
PubMed id		25592713
Abstract
The structure-activity relationships (SAR) of six-membered ring replacements for the imidazole ring scaffold is described. This work led to the discovery of the potent and selective pyridine (S)-23 and pyridinone (±)-24 factor XIa inhibitors. SAR and X-ray crystal structure data highlight the key differences between imidazole and six-membered ring analogs.