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Title
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Structural evidence for gene duplication in the evolution of the acid proteases.
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Authors
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J.Tang,
M.N.James,
I.N.Hsu,
J.A.Jenkins,
T.L.Blundell.
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Ref.
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Nature, 1978,
271,
618-621.
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PubMed id
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Abstract
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X-ray studies of acid proteases indicate a bilobal structure with a well defined
active site cleft. An intramolecular twofold symmetry axis relates two
topologically similar domains and the active site residues. A possible mechanism
for evolution by gene duplication, divergence and gene fusion is presented.
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