 |
|
Title
|
|
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines.
|
|
|
Authors
|
|
C.Bardelle,
D.Cross,
S.Davenport,
J.G.Kettle,
E.J.Ko,
A.G.Leach,
A.Mortlock,
J.Read,
N.J.Roberts,
P.Robins,
E.J.Williams.
|
|
|
Ref.
|
|
Bioorg Med Chem Lett, 2008,
18,
2776-2780.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
A series of bis-anilinopyrimidines have been identified as potent inhibitors of
the tyrosine kinase EphB4. Structural information from two alternative series
identified from screening efforts was combined to identify the initial leads.
|
|
|
|