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Abstract for PubMed entry 17981461 | ||
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| Title | |
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR. |
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| Authors | |
R.M.Angell, T.D.Angell, P.Bamborough, D.Brown, M.Brown, J.B.Buckton, S.G.Cockerill, C.D.Edwards, K.L.Jones, T.Longstaff, P.A.Smee, K.J.Smith, D.O.Somers, A.L.Walker, M.Willson. |
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| Ref. | |
Bioorg Med Chem Lett, 2008, 18, 324-328. |
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| PubMed id | |
17981461 |
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| Abstract | ||
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| The biphenyl amides are a novel series of p38 MAP kinase inhibitors. Structure-activity relationships of the series against p38alpha are discussed with reference to the X-ray crystal structure of an example. The series was optimised rapidly to a compound showing oral activity in an in vivo disease model. | ||
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