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Title
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A family of human cdc2-related protein kinases.
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Authors
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M.Meyerson,
G.H.Enders,
C.L.Wu,
L.K.Su,
C.Gorka,
C.Nelson,
E.Harlow,
L.H.Tsai.
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Ref.
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Embo J, 1992,
11,
2909-2917.
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PubMed id
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Abstract
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The p34cdc2 protein kinase is known to regulate important transitions in the
eukaryotic cell cycle. We have identified 10 human protein kinases based on
their structural relation to p34cdc2. Seven of these kinases are novel and the
products of five share greater than 50% amino acid sequence identity with
p34cdc2. The seven novel genes are broadly expressed in human cell lines and
tissues with each displaying some cell type or tissue specificity. The cdk3
gene, like cdc2 and cdk2, can complement cdc28 mutants of Saccharomyces
cerevisiae, suggesting that all three of these protein kinases can play roles in
the regulation of the mammalian cell cycle. The identification of a large family
of cdc2-related kinases opens the possibility of combinatorial regulation of the
cell cycle together with the emerging large family of cyclins.
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