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Title
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A comparison of viral RNA-dependent RNA polymerases.
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Authors
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C.Ferrer-Orta,
A.Arias,
C.Escarmís,
N.Verdaguer.
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Ref.
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Curr Opin Struct Biol, 2006,
16,
27-34.
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PubMed id
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Abstract
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Genome replication in picornaviruses is catalyzed by a virally encoded
RNA-dependent RNA polymerase, termed 3D. These viruses also use a small protein
primer, named VPg, to initiate RNA replication. The recent explosion of
structural information on picornaviral 3D polymerases has provided insights into
the initiation of RNA synthesis and chain elongation. Comparing these data with
results from previous structural analyses of viral RNA-dependent RNA polymerases
that catalyze de novo RNA synthesis sheds light on the different strategies that
these viruses use to initiate replication.
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