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Title
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A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection.
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Authors
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D.W.Borhani,
D.J.Calderwood,
M.M.Friedman,
G.C.Hirst,
B.Li,
A.K.Leung,
B.McRae,
S.Ratnofsky,
K.Ritter,
W.Waegell.
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Ref.
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Bioorg Med Chem Lett, 2004,
14,
2613-2616.
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PubMed id
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Abstract
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We have identified the pyrazolo[3,4-d]pyrimidine A-420983 (compound 7) as a
potent inhibitor of lck. A-420983 exhibits oral efficacy in animal models of
delayed-type hypersensitivity and organ transplant rejection.
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