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Abstract for PubMed entry 12358520 | ||
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| Title | |
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors. |
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| Authors | |
N.A.Dales, A.E.Gould, J.A.Brown, E.F.Calderwood, B.Guan, C.A.Minor, J.M.Gavin, P.Hales, V.K.Kaushik, M.Stewart, P.J.Tummino, C.S.Vickers, T.D.Ocain, M.A.Patane. |
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| Ref. | |
J Am Chem Soc, 2002, 124, 11852-11853. |
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| PubMed id | |
12358520 |
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| Abstract | ||
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| Angiotensin-converting enzyme-related carboxypeptidase (ACE2) is a recently identified zinc metalloprotease with carboxypeptidase activity that was identified using our genomics platform. We implemented a rational design approach to identify potent and selective ACE2 inhibitors. To this end, picomolar inhibitors of ACE2 were designed and synthesized. | ||
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