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Abstract for PubMed entry 11527704 | ||
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| Title | |
Evolution of anti-HIV drug candidates. Part 2: Diaryltriazine (DATA) analogues. |
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| Authors | |
D.W.Ludovici, R.W.Kavash, M.J.Kukla, C.Y.Ho, H.Ye, B.L.De Corte, K.Andries, M.P.de Béthune, H.Azijn, R.Pauwels, H.E.Moereels, J.Heeres, L.M.Koymans, M.R.de Jonge, K.J.Van Aken, F.F.Daeyaert, P.J.Lewi, K.Das, E.Arnold, P.A.Janssen. |
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| Ref. | |
Bioorg Med Chem Lett, 2001, 11, 2229-2234. |
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| PubMed id | |
11527704 |
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| Abstract | ||
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| A synthesis program directed toward improving the stability of imidoyl thiourea based non-nucleoside reverse transcriptase inhibitors (NNRTIs) led to the discovery of diaryltriazines (DATAs), a new class of potent NNRTIs. The synthesis and anti-HIV structure-activity relationship (SAR) studies of a series of DATA derivatives are described. | ||
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